By Victor R. Preedy, Ross J. Hunter
Adipokines (also referred to as adipocytokines) are a bunch of peptides secreted by way of adipose tissue. they've got varied roles, from services within the person phone to the full physique. This quantity examines a variety of particular adipokines in addition to their common mobile facets, together with thermal tension and adipokine expression, relevant frightened process roles for adiponectin in neuroendocrine and autonomic functionality, and astroglial leptin receptors. It discusses similar illnesses and prerequisites comparable to nonalcoholic fatty liver affliction, metabolic syndrome, center and rheumatic illnesses, and asthma and sleep problems.
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Additional resources for Adipokines, 1st Edition
Role for the alternative complement pathway in ischemia/reperfusion injury. Am. J. Pathol. 162: 449-455. © 2012 by Taylor & Francis Group, LLC 28 Adipokines Tao, Y. et al. 1997. Acylation-stimulating protein (ASP) regulates glucose transport in the rat L6 muscle cell line. Biochim. Biophys. Acta. 1344: 221-229. E. V. Narayana. 1996. Complement factor D, a novel serine protease. Protein Sci. 5: 553-564. T. et al. 1992. Human adipsin is identical to complement factor D and is expressed at high levels in adipose tissue.
In the mouse model of insulin deficiency, adipsin mRNA levels in adipose tissue were 2-3 times the level in normal mice (Miner et al. 1993). It is therefore suggested that insulin receptor signaling reduces the expression of adipsin. Adrenal glucocorticoid suppresses the expression of adipsin in genetically obese rat and mouse, and exogenous administration of glucocorticoid causes suppression in levels of adipsin mRNA and protein (Spiegelman et al. 1989). It is suggested that hyperglucocorticoid in certain obese models may be partially responsible for the lower adipsin levels in these models.
24 Suppl. 2: S142-143. Massiera, F. and M. Bloch-Faure, D. Ceiler, K. Murakami, A. M. Gasc, A. Quignard-Boulange, R. Negrel, G. Ailhaud, J. Seydoux, et al. 2001a. Adipose angiotensinogen is involved in adipose tissue growth and blood pressure regulation. FASEB J. 15: 2727-2729. Massiera, F. and J. Seydoux, A. Geloen, A. Quignard-Boulange, S. Turban, P. Saint-Marc, A. Fukamizu, R. Negrel, G. Ailhaud, and M. Teboul. 2001b. Angiotensinogen-deficient mice exhibit impairment of diet-induced weight gain with alteration in adipose tissue development and increased locomotor activity.