APC Proteins by Jennifer Kennell, Kenneth M. Cadigan (auth.), Inke S.

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By Jennifer Kennell, Kenneth M. Cadigan (auth.), Inke S. Näthke, Brooke M. McCartney (eds.)

Inke Näthke is the professor of Epithelial Biology on the collage of Dundee. Her examine curiosity is to figure out how particular molecular adjustments produce alterations in cells and eventually in complete tissues in the course of early phases of tumourigenesis. Her concentration is on colorectal cancers however the universal epithelial starting place of so much tumours makes this paintings appropriate to many different organs. Her paintings has led her to envision not just how cells movement and divide but additionally how they be aware of the place they're, and the way they interact to construct a practical tissue. Professor Näthke acquired her education at San Jose nation college, the college of California San Francisco, Stanford and Harvard clinical Schools.

Brooke McCartney is an Assistant Professor of organic Sciences at Carnegie Mellon college. She is attracted to how signaling pathways keep watch over the cytoskeleton and the way this ends up in adjustments in cytoskeletal and tissue structure. the point of interest of her lab is the function of APC proteins and Wnt signaling in morphogenesis, either on the point of the cytoskeleton and on the point of tissues, utilizing Drosophila melanogaster as a version procedure. Dr. McCartney got her education at Mount Holyoke university, Duke collage, and the college of North Carolina at Chapel Hill.

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4. Nathke IS, Adams CL, Polakis P, Sellin ]H, Nelson J. ] Cell Bioi 1996; 134:165 -179. 5. Wong MH, Hermiston ML, Syder A], Gordon]I. Forced expression of the tumor suppressor adenomatosis polyposis coli protein induces disordered cell migration in the intestinal epithelium. Proc Natl Acad Sci USA 1996; 93(18):9588-9593. 6. Anderson CB, Neufeld KL, White RL. Subcellular distribution of Wnt pathway proteins in normal and neoplastic colon. Proc Natl Acad Sci USA ]un 25 2002; 99(13):8683-8688. 7. Sena P, Saviano M, Monni S, Losi L, Roncucci L, Marzona L, Pol AD.

11. Zhang F, White R, Neufeld K. Phosphorylation ncar nuclear localization signal regulates nuclear import of APC protein. Pro. Natl Acad USA 2000; 97:12577-12582. 12. Koike M, Kose S, Furuta M, Taniguchi N, Yokoya F, Yoneda Y, Imarnoto N. ] Bioi Chern Aug 62004; 279(32 ):34038-34047. 13. Yokoya F, Imamoto N, Tachibana T, Yoneda Y. beta-catenin can be transported into the nucleus in a Ran-unassisted manner. Mol Bioi Cell 1999; 10(4):1119-1131. 14. Wiechens N, Fagotto F. CRMl- and Ran-independent nuclear export of beta-catenin.

3). Future experiments will surely clarify the broad range ofAPC activities as they relate to transcription control. Interaction ofAPC with DNA and Other Nuclear Proteins There is preliminary evidence for a direct interaction between APC and DNA. " Although it is puzzling that an APC truncation would retain both N- and C-terminal regions, three recombinant protein fragments , all from the C-terminal half ofAPC, bound plasmid DNA in mobility shift assays. Repetitive preparative mobility shift assays using two of these APC fragments revealed no consensus DNA binding sequence, but did suggest a higher affinity for A/T nucleotides vs G/C.

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